Live forever or die trying
“Henry Markram, a neuroscientist at the École Polytechnique Fédérale in Lausanne, Switzerland, has assembled a team of nine top European scientists for the research effort to build a computer model of a human brain. The Human Brain Project is in discussion with the EU for a £1billion (US$1.61 billion) grant.”
Hat tip to Rand Fitzpatrick.
high-stakes tests are often spectacularly bad at predicting performance in the real world. Though the SAT does a decent job of predicting the grades of college freshmen—the test accounts for about 12% of the individual variation in grade point average—it is much less effective at predicting levels of achievement after graduation. Professional academic tests suffer from the same flaw. A study by the University of Michigan Law School, for instance, found that LSAT scores bore virtually no relationship to career success as measured by levels of income, life satisfaction or public service.
Even the NFL Combine is a big waste of time. According to a recent study by economists at the University of Louisville, there’s no “consistent statistical relationship” between the results of players at the Combine and subsequent NFL performance.
The reason maximal measures are such bad predictors is rooted in what these tests don’t measure. It turns out that many of the most important factors for life success are character traits, such as grit and self-control, and these can’t be measured quickly.
Although the data from those early studies showed dismal results, I wasn’t discouraged. I still believed it was possible to significantly increase your cognitive functioning, given the proper training—since I had seen it with my own eyes through my work as a therapist.
Then in 2008, a very exciting study was published, Improving Fluid Intelligence with Training on Working Memory, by Jaeggi, Buschkuehl, Jonides, and Perrig. This study was pretty much a game-changer for those doing research on this topic. They showed for the first time, that it might actually be possible to increase your intelligence to a significant degree through training. What did they do different?
The subjects in Jaeggi’s study were trained on an intensive, multimodal (visual and auditory input) working memory task (the dual-n-back) [1] for variable lengths of time, for either one or two weeks, depending on the group. Following this training, they were tested to see how much they improved. As one would expect, after training, their scores on that task got better. But they went a step further. They wanted to see if those gains on the training task could transfer to an increase in skill on a completely different test of cognitive ability, which would indicate an increase in overall cognitive ability. What did they find?
Following training of working memory using the dual n-back test, the subjects were indeed able to transfer those gains to a significant improvement in their score on a completely unrelated cognitive task
By observing brain cancer patients before and after brain surgery, researchers in Italy have found that damage to the posterior part of the brain, specifically in an area called the parietal cortex, can increase patients’ feelings of “self transcendence,” or feeling at one with the universe. The parietal cortex is the region that is is usually involved in maintaining a sense of self, for example by helping you keep track of your body parts. It has also been linked to prayer and meditation [New Scientist].
The study, led by psychologist Cosimo Urgesi of the University of Udine in Italy, surveyed 88 brain cancer patients before and after surgery to remove their tumors. They were made to fill out a questionnaire regarding their beliefs, including a section to check their measure of “self-transcendence.” People score highly for this trait if they answer “yes” to questions such as: “I often feel so connected to the people around me that I feel like there is no separation”; “I feel so connected to nature that everything feels like one single organism”; and “I got lost in the moment and detached from time”. The same people also tend to believe in miracles, extrasensory perception and other non-material phenomena [New Scientist].
The scientists found that before the surgery, patients with parietal cortex tumors reported higher levels of self-transcendence than patients with tumors in the frontal cortex. After the tumors were removed, the parietal cortex patients had even higher self-transcendence scores, while the frontal cortex patients showed no change.
Via Alexis Bright.
Posted via web from crasch’s posterous
http://www.nytimes.com/2007/08/19/sports/playmagazine/0819play-brain.html?ex=1188273600&en=842c3ba0d994a5cf&ei=5070
“….Scientists have suspected for decades that exercise, particularly regular aerobic exercise, can affect the brain. But they could only speculate as to how. Now an expanding body of research shows that exercise can improve the performance of the brain by boosting memory and cognitive processing speed. Exercise can, in fact, create a stronger, faster brain.
This theory emerged from those mouse studies at the Salk Institute. After conducting maze tests, the neuroscientist Fred H. Gage and his colleagues examined brain samples from the mice. Conventional wisdom had long held that animal (and human) brains weren’t malleable: after a brief window early in life, the brain could no longer grow or renew itself. The supply of neurons — the brain cells that enable us to think — was believed to be fixed almost from birth. As the cells died through aging, mental function declined. The damage couldn’t be staved off or repaired.
Gage’s mice proved otherwise. Before being euthanized, the animals had been injected with a chemical compound that incorporates itself into actively dividing cells. During autopsy, those cells could be identified by using a dye. Gage and his team presumed they wouldn’t find such cells in the mice’s brain tissue, but to their astonishment, they did. Up until the point of death, the mice were creating fresh neurons. Their brains were regenerating themselves.
All of the mice showed this vivid proof of what’s known as “neurogenesis,” or the creation of new neurons. But the brains of the athletic mice in particular showed many more. These mice, the ones that scampered on running wheels, were producing two to three times as many new neurons as the mice that didn’t exercise.
But did neurogenesis also happen in the human brain? To find out, Gage and his colleagues had obtained brain tissue from deceased cancer patients who had donated their bodies to research. While still living, these people were injected with the same type of compound used on Gage’s mice. (Pathologists were hoping to learn more about how quickly the patients’ tumor cells were growing.) When Gage dyed their brain samples, he again saw new neurons. Like the mice, the humans showed evidence of neurogenesis.
….
This spring, neuroscientists at Columbia University in New York City published a study in which a group of men and women, ranging in age from 21 to 45, began working out for one hour four times a week. After 12 weeks, the test subjects, predictably, became more fit. Their VO2 max, the standard measure of how much oxygen a person takes in while exercising, rose significantly.
But something else happened as a result of all those workouts: blood flowed at a much higher volume to a part of the brain responsible for neurogenesis. Functional M.R.I.’s showed that a portion of each person’s hippocampus received almost twice the blood volume as it did before. Scientists suspect that the blood pumping into that part of the brain was helping to produce fresh neurons.
The hippocampus plays a large role in how mammals create and process memories; it also plays a role in cognition. If your hippocampus is damaged, you most likely have trouble learning facts and forming new memories. Age plays a factor, too. As you get older, your brain gets smaller, and one of the areas most prone to this shrinkage is the hippocampus. (This can start depressingly early, in your 30’s.) Many neurologists believe that the loss of neurons in the hippocampus may be a primary cause of the cognitive decay associated with aging. A number of studies have shown that people with Alzheimer’s and other forms of dementia tend to have smaller-than-normal hippocampi.
The Columbia study suggests that shrinkage to parts of the hippocampus can be slowed via exercise. The subjects showed significant improvements in memory, as measured by a word-recall test. Those with the biggest increases in VO2 max had the best scores of all.
“It’s reasonable to infer, though we’re not yet certain, that neurogenesis was happening in the people’s hippocampi,” says Scott A. Small, an associate professor of neurology at Columbia and the senior author of the study, “and that working out was driving the neurogenesis.”